Concurrent Chemoradiation, Adjuvant Durvalumab, and KEAP-1/NRF-2 Mutations: A Happy Marriage?
نویسندگان
چکیده
Adjuvant programmed death-ligand 1 blockade after concurrent chemoradiation (CCRT) for stage III NSCLC was found to significantly prolong progression free and overall survival1 at five-year follow-up of the PACIFIC phase 3 trial.2 Nevertheless, a significant proportion patients experience disease relapse factors underlying this phenomenon are not well understood. In issue Journal Thoracic Oncology, Sheridan et al.3 present welcomed retrospective analysis an institutional series with treated CCRT or without adjuvant durvalumab.
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ژورنال
عنوان ژورنال: Journal of Thoracic Oncology
سال: 2021
ISSN: ['1556-0864', '1556-1380']
DOI: https://doi.org/10.1016/j.jtho.2021.06.008